کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2823104 1161371 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics
چکیده انگلیسی

Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956–2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia–Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype.


► We inferred the evolutionary history of 310 DENV4 worldwide isolates.
► The serotype likely originated and spread from the area Malaysia–Thailand.
► Spreading dynamics for genotypes I and II was elucidated.
► Negative correlation on demographic time series suggest intra-serotype competition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 11, Issue 5, July 2011, Pages 878–885
نویسندگان
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