کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2823104 | 1161371 | 2011 | 8 صفحه PDF | دانلود رایگان |

Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956–2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia–Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype.
► We inferred the evolutionary history of 310 DENV4 worldwide isolates.
► The serotype likely originated and spread from the area Malaysia–Thailand.
► Spreading dynamics for genotypes I and II was elucidated.
► Negative correlation on demographic time series suggest intra-serotype competition.
Journal: Infection, Genetics and Evolution - Volume 11, Issue 5, July 2011, Pages 878–885