کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2823138 1161371 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolution of the influenza A virus untranslated regions
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Evolution of the influenza A virus untranslated regions
چکیده انگلیسی

In case of the influenza virus, untranslated regions are considered to possess plural functions. The specific packaging model suggests that each of eight segments contains a unique “packaging signal”, situated within the untranslated region and coding regions at the 5′ and 3′ ends of the genomic RNA. In addition to packaging signal, UTRs play key roles in polyadenylation and signals for genomic replication. In the present study, we report the evolutionary characteristics of untranslated regions of influenza virus.We analyzed 574 sequences of the human influenza A (H3N2) virus. The sequence of the untranslated region is highly conserved. Our analysis produced several observations regarding the untranslated region: (1) it has an extremely low divergence; (2) its evolutionary speed is not associated with the protein(s) it encodes; (3) its evolutionary rate is smaller than that of the open reading frame.We revealed the evolutionary characteristics of the untranslated region; this is the first study on the non-coding region of the influenza virus from the perspective of evolutionary molecular biology. In the future, clarifying the detailed mechanisms of packaging as well as the function of the RNA sequence in the untranslated region will increase the understanding of viral life cycles and evolution.


► We report evolution of untranslated regions of influenza virus.
► We analyzed 574 sequences of the human influenza A (H3N2) virus. Untranslated region is conserved well.
► Untranslated region possesses unique evolutionary characteristics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 11, Issue 5, July 2011, Pages 1150–1154
نویسندگان
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