کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2823597 1161395 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flagellin gene sequence evolution in Salmonella
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Flagellin gene sequence evolution in Salmonella
چکیده انگلیسی

Salmonella exhibits 70 serologically distinct flagellins, used internationally to diagnose and track infections. The terminal sequences of flagellin protein subunits are conserved in a range of bacteria and are here used as evolutionary markers to reveal how new serotypes arise. Terminal sequences of flagellins that exhibit factors g or m (G-group) were distinct from other Salmonella antigens (Non-G-group) and cluster more closely with Escherichia coli. It is postulated that G-group flagellins were inherited from a common ancestor of E. coli and Salmonella and that these antigens were among the original set in Salmonella. Sequence differences at the 5′ termini may prevent recombination between co-infecting strains. Evidence of increased variation of flagellin in rare biphasic G-group serotypes suggests that the presence of a second flagellin locus allows mutation of the G-group flagellin. FljB probably arose from a single duplication of a Non-G gene, since which synonymous mutations resulted in the fljB-specific sequence at the 5′ termini.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 7, Issue 4, July 2007, Pages 411–415
نویسندگان
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