کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2827354 1162437 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gender-specific antitumor action of aspirin in a murine model of a T-cell lymphoma bearing host
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Gender-specific antitumor action of aspirin in a murine model of a T-cell lymphoma bearing host
چکیده انگلیسی

Aspirin is an anti-inflammatory drug demonstrated to possess a tremendous anticancer potential. As progression of some tumors is influenced by sex hormones, we investigated if the antineoplastic action of aspirin shows gender dependence. Using a murine model of T-cell lymphoma, the present investigation was undertaken to study if the antitumor actions of aspirin against lymphoma cells display gender dimorphism. The findings of the present investigation indicate that aspirin administration to male and female tumor-bearing hosts resulted in gender dependent differential tumor growth retardation. Such gender dichotomy of aspirin's antitumor action was associated with a differential impact on cell cycle progression and expression of cell survival regulatory molecules. Aspirin administration was also found to modulate crucial parameters of tumor microenvironment, including contents of glucose, lactate and cell growth regulatory cytokines, in a gender specific manner. Aspirin was found to reverse estrogen-dependent augmentation of tumor cell survival in vitro. Taken together the results of the present study suggest that the antineoplastic action of aspirin is gender-dependent and should be considered in designing of gender-specific therapeutic applications of aspirin.


► Aspirin shows gender-dependent antineoplastic action.
► The antitumor actions of aspirin are modulated by androgen and estrogen.
► Aspirin alters tumor microenvironment and expression of cell survival regulatory molecules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 48, Issue 2, 15 February 2012, Pages 137–144
نویسندگان
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