کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2829445 | 1162809 | 2007 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Continuous representations of proteins: Construction of coordinate models from curvature profiles
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
A representation of proteins based on the geometry of space curves is described. This representation enables the application of continuum methods to the analysis of macromolecular structure and form that cannot be applied to the more familiar discrete atomic coordinate models. It is shown that the continuous modeling method defines the geometry of the protein fold very efficiently. An analytical solution for curve construction is employed from which both continuous and coordinate models can be obtained. The method is applied to five representative test proteins which are used to assess the accuracy and efficiency of the modeling procedure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 158, Issue 3, June 2007, Pages 267–281
Journal: Journal of Structural Biology - Volume 158, Issue 3, June 2007, Pages 267–281
نویسندگان
A.C. Hausrath, A. Goriely,