کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2832769 | 1163844 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A common idiotype in IgE and its relation to recognition of the grass pollen allergen Phl p 2
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A common idiotype in IgE and its relation to recognition of the grass pollen allergen Phl p 2 A common idiotype in IgE and its relation to recognition of the grass pollen allergen Phl p 2](/preview/png/2832769.png)
چکیده انگلیسی
The variable regions of allergen-specific IgE, the isotype mediating allergic responses, are poorly defined to date. In this study we define the character of human antibody binding sites recognizing Phl p 2, a major allergen from timothy grass pollen. Independently raised specificities developed by phage display technology tended to have common sequence motifs (idiotypes), such as IGHV4-31 germline gene origin and heavy chain complementarity-determining region (CDR) 3 length and sequence. They also combined with highly related light chain sequences. Such heavy chain variable domain-encoding transcripts have also been found in the IgE-encoding transcriptome of yet other grass pollen allergic subjects. Altogether these data argue that a common idiotype is used to establish specific antibodies with a potential to mediate allergic responses to Phl p 2. Such a restriction may contribute to the limited molecular diversity observed in some IgE populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 45, Issue 9, May 2008, Pages 2715-2720
Journal: Molecular Immunology - Volume 45, Issue 9, May 2008, Pages 2715-2720
نویسندگان
Helena Persson, Sabine Flicker, Mardjaneh Karbalaei Sadegh, Lennart Greiff, Rudolf Valenta, Mats Ohlin,