کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2833234 | 1163862 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Does complement factor B have a role in the pathogenesis of atypical HUS?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Does complement factor B have a role in the pathogenesis of atypical HUS? Does complement factor B have a role in the pathogenesis of atypical HUS?](/preview/png/2833234.png)
چکیده انگلیسی
Atypical haemolytic uraemic syndrome (aHUS) is a disorder of complement dysregulation. Because complement factor B (fB) carries the catalytic site of the alternative pathway convertase we examined it as both a potential candidate gene and modifier in the pathogenesis of aHUS. No factor B gene (BF) mutations were found in 20 patients with aHUS. There was no statistical difference between controls and aHUS patients in either BF allele or haplotype frequency. In conclusion, in this small series of aHUS patients we found no evidence that fB has a major role in the pathogenesis of aHUS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 43, Issue 7, March 2006, Pages 856-859
Journal: Molecular Immunology - Volume 43, Issue 7, March 2006, Pages 856-859
نویسندگان
David Kavanagh, Elizabeth J. Kemp, Anna Richards, Rachel M. Burgess, Elizabeth Mayland, Judith A. Goodship, Timothy H.J. Goodship,