کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2833513 | 1570746 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Complement and Toll-like receptors: Key regulators of adaptive immune responses Complement and Toll-like receptors: Key regulators of adaptive immune responses](/preview/png/2833513.png)
The innate immune system provides sophisticated defense mechanisms to protect complex macroorganisms from the attack of microorganisms. Among those, the complement system and Toll-like receptors are of paramount importance to discriminate between infectious non-self and non-infectious self and to provide critical danger signals instructing adaptive immune responses. Here, we will discuss recent advances in our understanding of the mechanisms underlying complement and TLR-mediated regulation of adaptive immunity. We will focus on the regulation of T cell immunity and discuss recent findings on the cross-talk between complement receptor and TLR signaling pathways. Such cross-talk is likely to affect the outcome of infections with intracellular pathogens, as well as the initiation and maintenance of aberrant immune responses leading to autoimmunity and atopy.
Journal: Molecular Immunology - Volume 43, Issues 1–2, January 2006, Pages 13–21