کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2834155 | 1164292 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Phylogenetic history of paralogous gene quartets on human chromosomes 1, 2, 8 and 20 provides no evidence in favor of the vertebrate octoploidy hypothesis Phylogenetic history of paralogous gene quartets on human chromosomes 1, 2, 8 and 20 provides no evidence in favor of the vertebrate octoploidy hypothesis](/preview/png/2834155.png)
Fourfold paralogy regions in the human genome have been considered historical remnants of whole-genome duplication events predicted to have occurred early in vertebrate evolution. Taking advantage of the well-annotated and high-quality human genomic sequence map as well as the ever-increasing accessibility of large-scale genomic sequence data from a diverse range of animal species, we investigated the prediction that the ancestral vertebrate genome was shaped by two rapid rounds of whole-genome duplication within a period of 10 million years. Both the map self-comparison approach and a phylogenetic analysis revealed that gene families identified as tetralogous on human chromosomes 1/2/8/20 arose by small-scale duplication events that occurred at widely different time points in animal evolution. Furthermore, the data discount the likelihood that tree topologies of the form ((A,B)(C,D)) are best explained by the octoploidy hypothesis. We instead propose that such symmetrical tree patterns are also consistent with local duplications and rearrangement events.
Figure optionsDownload as PowerPoint slideHighlights
► Validity of vertebrate octoploidy hypothesis was tested.
► Phylogenetic history of multigene-families residing on HSA 1/2/8/20.
► Human tetralogous genomic segments were created by small scale duplication events.
► Data discounts the likelihood of two closely spaced rounds of tetraploidy events.
Journal: Molecular Phylogenetics and Evolution - Volume 63, Issue 3, June 2012, Pages 922–927