Control of anesthesia-induced hypothermia by ambient temperature regulation in rats

(1)The goal of this study was to control anesthesia-induced hypothermia in rats, which was addressed through four experimental steps.(2)First, identify the effects of isoflurane anesthetic on Sprague-Dawley rats at an ambient temperature of 23 °C.(3)Second, determine an ambient temperature that is thermo-neutral and counteracts anesthesia hypothermia.(4)Third, test the calculated thermo-neutral point.(5)Fourth, identify differences in colonic temperature response to different body weights and to calorie-restricted animals.(6)Our findings showed there were differences in core temperature response and skin adipose deposition between 350 and 450 g rats.(7)Also there was a greater hypothermic trend in rats that were calorie restricted to 350 g vs. ad libitum fed 350 g rats.