Effect of cold on lipid peroxidation in the brown adipose tissue and liver of rats

1. Lipid peroxidation in the interscapular brown adipose tissue (iBAT) and liver was studied in rats acclimated to room (23±1 °C) and low temperature (5±1 °C, 42 days), as well as in animals exposed to 5±1 °C for 24 h; in addition, the tissue metallothionein (MT) and iron were determined.2. The short- and long-term cold exposure did not affect lipid peroxidation in the iBAT, but increased the process in the liver.3. The tissue MT analysis showed that the protein might protect iBAT but not liver against oxidative damage, especially during short-term cold exposure.4. The tissue iron analysis revealed that there was no direct relationship of the total tissue Fe to lipid peroxidation during cold exposure.