کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2844098 1571169 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Operant self-administration of ethanol in infant rats
ترجمه فارسی عنوان
خودکارآمدی اتانول در موشهای نوزادی
کلمات کلیدی
اتانول، شرطیسازی عامل، موش نوزاد گیرنده های اپیدمی اندوژن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


• The infant rat is highly sensitive to appetitive motivational effects of ethanol.
• Operant response to ethanol in infancy is enhanced by exposure to ethanol in utero.
• Operant response to ethanol in infancy is mediated by opioid transmission.
• Operant response to ethanol can facilitate subsequent ethanol intake.

The review focuses on operant self-administration of ethanol in immature, infant rats. Several methods for the analysis of ethanol intake in infants are available, yet only oral self-administration models the typical pattern of ethanol consumption found in humans. The study of ethanol intake in infants is important for our understanding of how early alcohol experiences facilitate subsequent engagement with alcohol. It seems that sensitivity to ethanol-induced operant reinforcement is found very early in life, a few hours after birth, and throughout the first three weeks of life. Most of the studies reviewed complied with most, albeit not all, of the criteria for operant behavior (e.g., greater responding than yoked controls and persistence of this difference after withholding the reinforcer). Operant self-administration of ethanol in infant rats seems to be, at least partially, mediated by endogenous opioid transmission and can be enhanced by prior exposure to ethanol. Furthermore, acquisition of ethanol-mediated operant learning seems to facilitate drug self-administration during adolescence. Relative to older subjects, infants exhibit lower sensitivity to ethanol's sedative, hypnotic and motor impairing effects. On the other hand, they exhibit increased sensitivity to the motor stimulant and rewarding effects of ethanol. We suggest that this pattern of response to ethanol may favor the rapid acquisition of operant self-administration in infant rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 148, 1 September 2015, Pages 87–99
نویسندگان
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