کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2844960 | 1166372 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain distribution of genes related to changes in locomotor activity
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کلمات کلیدی
STRoLFRHPPALMOBhpfCTXStriatum - استریاتومAMY - امیmRNA expression - بیان mRNAThalamus - تالاموسhippocampal formation - تشکیل هیپوکامپsubstantia nigra - توده سیاهexploration - جهانگردی یا اکتشافSpinal cord - طناب نخاعیLocomotor activity - فعالیت locomotorfrontal cortex - قشر جلوییcerebral cortex - قشر مغزCerebellum - مخچهMedulla - مدولاHIP - مفصل ران یا مفصل هیپMice - موشMidbrain - میانمغز، مزانسفالknockout - ناکاوتHypothalamus - هیپوتالاموسHippocampus - هیپوکامپ Pallidum - پالیدومPons - پونز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
These three groups of genes belonged to overlapping neurotransmitter systems or cellular functions. Therefore, we postulated that a better predictor of the locomotor behavior resulting from gene deletion might be the brain expression pattern. To this aim we correlated the brain expression of the genes and the locomotor activity resulting from the deletion of the same genes, using two databases (Allen Brain Atlas and SymAtlas). The results showed that the deletion of genes with higher expression level in the brain had higher probability to be accompanied by increased behavioral activity. Moreover the genes that were accompanied by locomotor hyperactivity when deleted, were more expressed in the cerebral cortex, amygdala and hippocampus compared to the genes unrelated to locomotor activity. Therefore, the prediction of the behavioral effect of a gene should take into consideration its brain distribution. Moreover, data confirmed that genes highly expressed in the brain are more likely to induce hyperactivity when deleted. Finally, it is suggested that gene mutations linked to specific behavioral abnormalities (e.g. inattention) might probably be associated to hyperactivity if the same gene has elevated brain expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 99, Issue 5, 19 April 2010, Pages 618-626
Journal: Physiology & Behavior - Volume 99, Issue 5, 19 April 2010, Pages 618-626
نویسندگان
Pasquale Mignogna, Davide Viggiano,