کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2845382 | 1571212 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interferon-α-induced deficits in novel object recognition are rescued by chronic exercise
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
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چکیده انگلیسی
The anti-viral drug interferon-alpha (IFN-α) is widely-known to induce psychiatric and cognitive effects in patients. Previous work has shown that physical exercise can have a positive effect against brain insult. We investigated the effects of a clinically-comparable treatment regime of IFN-α on cognitive function in male Wistar rats and assessed the impact of chronic treadmill running on the deficits generated by IFN-α. We found that IFN-α induced significant impairments in performance on both spatial novelty and object novelty recognition. Chronic forced exercise did not protect against IFN-α-induced learning deficits in reactivity to spatial change, but did restore the capacity for novel object recognition in IFN-α-treated animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 95, Issues 1–2, 3 September 2008, Pages 125–129
Journal: Physiology & Behavior - Volume 95, Issues 1–2, 3 September 2008, Pages 125–129
نویسندگان
Bríana Fahey, Sally Barlow, Jennifer S. Day, Shane M. O'Mara,