کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2846085 1166409 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain serotonin depletion impairs short-term memory, but not long-term memory in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Brain serotonin depletion impairs short-term memory, but not long-term memory in rats
چکیده انگلیسی

Intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) (150 μg; 4.5 μl/ventricle), a serotonergic neurotoxin, significantly decreased spontaneous alternation in Y-maze task and working memory in radial 8 arm-maze task, suggesting effects on short-term memory, without affecting long-term memory, explored by reference memory in radial 8 arm-maze task and step-through latency in multi-trial passive avoidance task. Parachlorophenylalanine (PCPA) (3 days treatment 200 μg, i.c.v.), a serotonin synthesis inhibitor, did not impair step-through-latency in multi-trial passive avoidance task, suggesting no effects on long-term memory. These results suggest that serotonin, among other neurotransmitters, play an important role in cognitive functions, especially short-term memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 91, Issue 5, 15 August 2007, Pages 652–657
نویسندگان
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