کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2846487 1166423 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peripheral triiodothyronine (T3) levels during escapable and inescapable footshock
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Peripheral triiodothyronine (T3) levels during escapable and inescapable footshock
چکیده انگلیسی

Changes in peripheral thyroid hormone levels are associated with changes in human affective disorders, particularly depression. In the current study we used an animal stress paradigm, proposed to be an animal model of depression, to examine peripheral T3 levels during and after escapable or inescapable stress in adult male rats. In this model, one animal can control the termination of foot-shock stress by performing a lever press, and therefore experiences escapable stress. His lever press also terminates the shock for his yoked partner, who has no control over the stressor, and therefore experiences inescapable stress. In three separate experiments, blood samples were collected during and after one or two sessions of escapable/inescapable stress. We found that exposure to inescapable stress, but not escapable stress, caused a decrease in T3 levels 120 min post-stress initiation. Peripheral T3 levels were not significantly altered in animals exposed to escapable stress. In sum, these results add to a large body of previous data indicating that psychological coping can prevent the effects of physical stress on many diverse systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 87, Issue 1, 30 January 2006, Pages 114–119
نویسندگان
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