کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2848104 | 1167405 | 2008 | 5 صفحه PDF | دانلود رایگان |
In order to examine whether ATP-sensitive potassium channel Kir6.2 is involved in hypoxic ventilatory responses, especially in hypoxic ventilatory depression (HVD), and whether the involvement shows age-dependence, we measured the hypoxic ventilatory response in the Kir6.2-knockout mouse (Kir6.2−/−) in an unanesthetized unrestrained state by means of pressure plethysmography in the 2nd and 4th postnatal weeks, and compared the response with that of its wild type counterpart, the C57BL6/J mouse. In the 4th postnatal week, but not in the 2nd week, the Kir6.2−/− exhibited a larger and longer initial augmentation and a weaker subsequent depression of respiratory frequency and ventilation in response to hypoxia (FIO2 = 0.12 in N2). These findings suggest that Kir6.2 is involved in HVD of the mouse at a certain point during the postnatal development.
Journal: Respiratory Physiology & Neurobiology - Volume 162, Issue 1, 30 June 2008, Pages 80–84