Keywords: هدف ژن; Plant transformation; Gene Targeting; Homologous recombination; Zinc finger nuclease; Clustered regularly interspaced short palindrome repeats; Transcription activator-like effector nucleases;
مقالات ISI هدف ژن (ترجمه نشده)
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Keywords: هدف ژن; animal model; gene targeting; knockout; renal physiology; urine concentration;
Keywords: هدف ژن; Disease model; Oncopig; Cancer; Gene targeting; Transgenic;
Keywords: هدف ژن; Gene targeting; Pluripotent stem cells; Extracellular matrix; Cardiac function;
Keywords: هدف ژن; Zinc-finger nucleases; Beta lactoglobulin; Fusion protein; Gene targeting; Direct protein delivery
Keywords: هدف ژن; ASIC; Gene targeting; Knockout; Mechanotransduction; Pain; Phenotype;
Keywords: هدف ژن; Zebrafish; Gene targeting; Homologous recombination; CRISPR/Cas9; Germline transmission;
Keywords: هدف ژن; Cancer models; Gene targeting; Transgenics; PDX; Cas9;
Keywords: هدف ژن; Transcription activator-like effectors; TALE transcription factors; TALE nucleases; Genome editing; Gene targeting
Keywords: هدف ژن; ColA1; α1 (I) procollagen locus; puro; Puromycin N-acetyl-transferase gene; hygro; hygromycin resistance gene; HR; homologous recombination; SCNT; somatic cell nuclear transfer; DT-A; diphtheria toxin A gene; CMV; cytomegalovirus; EGFP; enhanced green fl
New multi-marker strains and complementing genes for Aspergillus nidulans molecular biology
Keywords: هدف ژن; Aspergillus; Gene targeting; Transformation; Deletions; Selectable markers;
ReviewGenetic strategies to analyze primary TRP channel-expressing cells in mice
Keywords: هدف ژن; TRP channels; TRPM5; Gene targeting; Homologous recombination; Knock-in; Genetic labeling; Internal ribosomal entry site; Cre recombinase; ROSA26; ÏGFP;
Towards mastering CRISPR-induced gene knock-in in plants: Survey of key features and focus on the model Physcomitrella patens
Keywords: هدف ژن; CRISPR-Cas9 system; Gene knock-in; Genome editing; Gene targeting; Physcomitrella patens;
Deletion of ligD significantly improves gene targeting frequency in the lignocellulolytic filamentous fungus Penicillium oxalicum
Keywords: هدف ژن; DNA ligase IV; Gene targeting; Homologous integration; Non-homologous end-joining; Selectable marker;
Disruption of ku70 involved in non-homologous end-joining facilitates homologous recombination but increases temperature sensitivity in the phytopathogenic fungus Penicillium digitatum
Keywords: هدف ژن; Citrus fruit; Gene targeting; Chitin synthase; Fungal transformation
Principles of genetic variations and molecular diseases: applications in hemophilia A
Keywords: هدف ژن; Hemophilia A; Gene targeting; F8 gene mutations; Mutation analysis; CNV; Inversion; Molecular Biology methods;
Genome Editing: From Drosophila to Non-Model Insects and Beyond
Keywords: هدف ژن; Insect transgenesis; Drosophila; Black soldier fly; Gene targeting; Site-specific recombination; Piggybac transposon;
Common mechanisms in development and disease: BMP signaling in craniofacial development
Keywords: هدف ژن; Craniofacial development; Craniofacial malformations; Tooth morphogenesis; Cleft palate; BMP signaling; Gene targeting; Congenital malformations
Research articleEfficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system
Keywords: هدف ژن; Cattle; Ruminant; Bovine spongiform encephalopathy; Mad cow disease; Engineered nuclease; Gene targeting;
Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives
Keywords: هدف ژن; Human induced pluripotent stem cell (iPSC); AAVS1; Gene targeting; Nuclease; TALEN; CRISPR/Cas9;
Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells
Keywords: هدف ژن; B cell development; DT40; Epigenetics; Gene targeting; Histone acetyltransferase; Bach2; BTB and CNC homology 2; Bcl-6; B cell lymphoma-6; Blimp-1; B lymphocyte-induced maturation protein-1; ChIP; chromatin immunoprecipitation; EBF1; early B cell factor 1
Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression
Keywords: هدف ژن; Apoptosis; Bcl-2; ER stress; GCN5; Gene targeting; AFT4; activating transcription factor 4; AFT6; activating transcription factor 6; Bax; B-cell lymphoma-associated X; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-large; CHOP; C/EBP-homologous p
Disruption of lig4 improves gene targeting efficiency in the oleaginous fungus Mortierella alpina 1S-4
Keywords: هدف ژن; HR; homologous recombination; NHEJ; none homologousend joining; DSBs; DNA double-strand breaks; OA; oleic acid; LA; linoleic acid; GLA; γ-linolenic acid; DGLA; dihomo-γ-linolenic acid; ARA; arachidonic acid; DNA ligase 4 (lig4); Homologous recombination
Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility
Keywords: هدف ژن; C4BP; C4b-binding protein; EpC4BP; epididymal C4BP; DAF; decay accelerating factor; MCP; membrane cofactor protein; LDLR; low-density lipoprotein receptor; LRP; low-density lipoprotein receptor-related protein; SCR; short consensus repeat; WT; wild type;
Quantifying on- and off-target genome editing
Keywords: هدف ژن; gene editing; gene targeting; homologous recombination; nonhomologous end-joining; ZFNs; TALENs; CRISPR/Cas9; RNA-guided endonucleases
A modular gene targeting system for sequential transgene stacking in plants
Keywords: هدف ژن; Aad1; Aryloxyalkanoate dioxygenase; BC; Backcrossed; eZFN; Engineered zinc finger nuclease; Osubi3; Rice ubiquitin3; Pat; Phosphinothricin acetyl transferase; Phiyfp; Yellow fluorescent protein; SCBV; Sugarcane bacilliform virus; Taper; Wheat peroxidase;
The CRISPR/Cas9 system for plant genome editing and beyond
Keywords: هدف ژن; CRISPR; Cas9; Site-specific nuclease; Genome editing; Targeted mutagenesis; Gene targeting; Plants;
Disruption of tubular Flcn expression as a mouse model for renal tumor induction
Keywords: هدف ژن; BHD; FLCN; gene targeting; kidney cancer; mouse model; mTOR; RCC; TGF-β;
Pullulan and pullulan derivatives as promising biomolecules for drug and gene targeting
Keywords: هدف ژن; Pullulan; Polysaccharide; Drug delivery; Drug release; Gene targeting; Nanoparticles;
Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells
Keywords: هدف ژن; 5â²-RACE; 5â²-rapid amplification of cDNA ends; BCR; B cell receptor; ChIP; chromatin immunoprecipitation; EBF1; early B cell factor 1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; H3K14; Lys-14 of histone H3; H3K9; Lys-9 of histone H3; HAT; histone
Genome engineering with TALENs and ZFNs: Repair pathways and donor design
Keywords: هدف ژن; ZFNs; TALENs; DNA repair; Gene targeting; NHEJ; Homologous recombination;
Targeted disruption of Ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer
Keywords: هدف ژن; Somatic cell nuclear transfer; Ataxia telangiectasia mutated; Gene targeting; Miniature pigs;
Direct gene disruption by TALENs in medaka embryos
Keywords: هدف ژن; GD, gene disruption; Hm, homoduplex; Ht, heteroduplex; TALEN, transcription activator-like effector nucleasednd; Gene disruption; Genome editing; Gene targeting; TALEN
Manipulation of epigenetic factors and the DNA repair machinery for improving the frequency of plant transformation
Keywords: هدف ژن; C-NHEJ; canonical NHEJ; DSBs; DNA double-strand breaks; gDNA; genomic DNA; GT; gene targeting; HR; homologous recombination; NHEJ; non-homologous end joining; PTGS; posttranscriptional gene silencing; RNAi; RNA interference; rat; resistant to Agrobacteriu
One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering
Keywords: هدف ژن; Cas9; Multiple; Gene targeting; Immunodeficient; Mouse;
Biallelic targeting of expressed genes in mouse embryonic stem cells using the Cas9 system
Keywords: هدف ژن; Gene targeting; Double-strand break (DSB); Cas9; Embryonic stem cells; Genome editing; Homologous recombination;
Generation of targeted mouse mutants by embryo microinjection of TALENs
Keywords: هدف ژن; Knockin; Knockout; One-cell embryo; Gene targeting; TALEN; Mouse;
FibromiRs: translating molecular discoveries into new anti-fibrotic drugs
Keywords: هدف ژن; miRNA; fibrosis; therapeutics; drug design; gene targeting
Physiological roles of long noncoding RNAs: insight from knockout mice
Keywords: هدف ژن; lncRNA; genetic study; gene targeting; knockout; phenotype
Methods for targeted mutagenesis in zebrafish using TALENs
Keywords: هدف ژن; Site-specific nuclease; Transcription activator-like effector nuclease; Knockout; Genome engineering; Gene targeting; Gene disruption; Zebrafish
Targeted genome engineering techniques in Drosophila
Keywords: هدف ژن; TALEN; CRISPR; Zinc finger nuclease; Gene targeting; Drosophila; Nuclease; NHEJ; Homologous recombination;
D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells
Keywords: هدف ژن; Cyclin D; Gene targeting; Tetracycline transactivator; ErbB2; Mammary gland development; Breast cancer;
Tracing the fates of site-specifically introduced DNA adducts in the human genome
Keywords: هدف ژن; TATAM; tracing DNA adducts in targeted mutagenesis; 8-oxoG; 8-oxo-7,8-dihydroguanine; TK; thymidine kinase gene; HR; homologous recombination; DSB; double-strand break; MYH; human MutY homolog; DNA adducts; Mutagenesis; Gene targeting; 8-Oxoguanine (8-oxo
Sgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting
Keywords: هدف ژن; HR; homologous recombination; EOGT; ends-out gene targeting; EIGT; ends-in gene targeting; DSB; double-strand break; TCD; targeted chromosome duplication; BIR; break-induced replication; bp; base pair; kb; kilobase; nt; nucleotide; PFGE; pulsed-field gel
DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells
Keywords: هدف ژن; Double-strand break repair; Non-homologous end joining; Ku; Ligase III; Ligase IV; Gene targeting; C-NHEJ; A-NHEJ; Homologous recombination;
Cre-loxP-based system for removal and reuse of selection markers in Ashbya gossypii targeted engineering
Keywords: هدف ژن; Ashbya gossypii; Cre-loxP system; Gene targeting; Marker recycling; Recombinase expression;
Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes
Keywords: هدف ژن; Gene targeting; Pigmentation; Knockout; Mosaic; Genome editing; Melanocyte;
Generation and characterization of a conditional deletion allele for Lmna in mice
Keywords: هدف ژن; Lamins; Laminopathies; Lmna; Conditional knockout; Gene targeting; Cre-loxP;
Efficient gene targeting in Penicillium chrysogenum using novel Agrobacterium-mediated transformation approaches
Keywords: هدف ژن; Gene targeting; Agrobacterium-mediated transformation; Penicillium chrysogenum; Non-homologous end joining; Bi-partite method;
Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis
Keywords: هدف ژن; EGFR; Epigen; Gene targeting; Knockout mouse;