کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870745 1074019 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells
چکیده انگلیسی
In this study, we revealed that GCN5 and early B cell factor 1 (EBF1) participate in regulation of protein kinase Cθ (PKCθ) gene expression in an opposite manner in immature B cells. GCN5-deficiency in DT40 caused drastic down-regulation of transcription of PKCθ. In contrast, EBF1-deficiency brought about remarkable up-regulation of that of PKCθ, and re-expression of EBF1 dramatically suppressed transcription of PKCθ. Chromatin immunoprecipitation assay revealed that GCN5 binds to the 5′-flanking region of the chicken PKCθ gene and acetylates histone H3, and EBF1 binds to the 5′-flanking region of the gene surrounding putative EBF1 binding motifs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 9, 2 May 2014, Pages 1739-1742
نویسندگان
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