کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848134 1571349 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient mucociliary transport relies on efficient regulation of ciliary beating
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Efficient mucociliary transport relies on efficient regulation of ciliary beating
چکیده انگلیسی

The respiratory mucociliary epithelium is a synchronized and highly effective waste-disposal system. It uses mucus as a vehicle, driven by beating cilia, to transport unwanted particles, trapped in the mucus, away from the respiratory system. The ciliary machinery can function in at least two different modes: a low rate of beating that requires only ATP, and a high rate of beating regulated by second messengers. The mucus propelling velocity is linearly dependent on ciliary beat frequency (CBF). The linear dependence implies that a substantial increase in transport efficiency requires an equally substantial rise in CBF. The ability to enhance beating in response to various physiological cues is a hallmark of mucociliary cells. An intricate signaling network controls ciliary activity, which relies on interplay between calcium and cyclic nucleotide pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 163, Issues 1–3, 30 November 2008, Pages 202–207
نویسندگان
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