کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2848451 | 1167423 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanical limitation during CO2 rebreathing in young patients with cystic fibrosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mechanical limitation during CO2 rebreathing in young patients with cystic fibrosis Mechanical limitation during CO2 rebreathing in young patients with cystic fibrosis](/preview/png/2848451.png)
چکیده انگلیسی
The aim of the study was to determine whether a decrease in the ventilatory response to carbon dioxide (CO2) in children with cystic fibrosis (CF) is related to a mechanical limitation of the respiratory muscle capacity. The ventilatory response during CO2 rebreathing was performed in 15 patients (mean forced expiratory volume in 1 s (FEV1): 37 ± 21% predicted, mean arterial CO2: 41 ± 5 mmHg). The slope of the minute ventilation normalised for weight per mmHg CO2 increment correlated negatively with respiratory muscle output, assessed by the oesophageal (p = 0.002), the diaphragmatic pressure time product (p = 0.01), and the tension time index (p = 0.005). In addition, this slope was correlated with dynamic lung compliance (p < 0.0001) and FEV1 (p = 0.03) but not with airway resistance and maximal transdiaphragmatic pressure. Therefore, an excessive load imposed on the respiratory muscles explains the blunting of the ventilatory response to CO2 in young patients with CF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 153, Issue 3, 27 October 2006, Pages 217-225
Journal: Respiratory Physiology & Neurobiology - Volume 153, Issue 3, 27 October 2006, Pages 217-225
نویسندگان
Brigitte Fauroux, Frédéric Nicot, Pierre-Yves Boelle, Michèle Boulé, Annick Clément, Frédéric Lofaso, Monique Bonora,