کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2853397 | 1572131 | 2015 | 6 صفحه PDF | دانلود رایگان |
The purpose of this study was to evaluate long-term changes of transplant coronary arteries, including vessel, plaque, and lumen areas. There are limited long-term data on vessel remodeling after heart transplantation. We analyzed serial intravascular ultrasound images of the left anterior descending coronary artery (LAD) in 54 heart transplantation recipients. Nine patients (16.7%) had a history of rejection. Proximal left anterior descending artery segments were matched among time points, a ≥20-mm long segment was analyzed every 1 mm, and results were normalized for analysis length and reported as mm3/mm. During follow-up, vessel area decreased (−0.48 ± 1.3 mm3/mm/year), and plaque area did not change (−0.01 ± 0.47 mm3/mm/year). As a result, lumen area decreased (−0.52 ± 1.34 mm3/mm/year). The change in mean lumen area was well correlated to the change in mean vessel area (r = 0.94, p <0.01) but not to the change in mean plaque area (r = −0.27, p = 0.05). In conclusion, lumen loss occurred during long-term follow-up of patients who underwent heart transplantation, primarily secondary to negative remodeling (decrease in vessel dimensions).
Journal: The American Journal of Cardiology - Volume 116, Issue 5, 1 September 2015, Pages 785–790