کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2861136 1572382 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Folic Acid on Endothelial Function Following Acute Myocardial Infarction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of Folic Acid on Endothelial Function Following Acute Myocardial Infarction
چکیده انگلیسی

The aim of this study was to test the influence of high-dose folic acid (10 mg/d) on endothelial function in patients referred for coronary intervention after an acute myocardial infarction (AMI) and determine its relation to homocysteine levels. Flow-mediated dilation (FMD) of the brachial artery was performed in 40 patients after AMI (16 with normal homocysteine levels and 24 patients with elevated levels [>11 μmol/L]). Subjects were randomized to receive first folic acid (10 mg/day; group A) or placebo (group B) for 6 weeks in a double-blind crossover trial with a 2-week washout. Plasma folate, total homocysteine and its subtypes (oxidized, reduced, and protein-bound), FMD, and nitroglycerin-mediated dilation were assessed at baseline and at 6 and 14 weeks. In group A, folic acid improved FMD from 3.98 ± 0.35% to 6.44 ± 0.56% (p <0.001). This effect persisted after the crossover with placebo (5.42 ± 0.59, p = 0.13). In group B, placebo did not increase FMD (4.01 ± 0.34% vs 4.46 ± 0.38, p = 0.38); however, a significant increase was observed in the second active treatment period (6.49 ± 0.56%, p = 0.005). In both groups, improved FMD neither correlated with basal levels of homocysteine and its subtypes nor with changes induced during the folate treatment. Nitroglycerin-mediated dilation did not change significantly in either group. Folic acid increased FMD in both normo- and hyperhomocysteinanemic groups (p = 0.006 and p <0.001). In conclusion, 6-week treatment with high-dose folic acid improves endothelial function in post-AMI patients, independent from homocysteine status. Folic acid can be recommended to improve postinfarction endothelial dysfunction in patients with normo- and hyperhomocysteinemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Cardiology - Volume 99, Issue 4, 15 February 2007, Pages 476–481
نویسندگان
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