Does Blockade of the Renin Angiotensin System Affect Sympathetic and Blood Pressure Responses to Amlodipine in Young Hypertensive Patients?

It appears that amlodipine does not activate the renin-angiotensin system to counteract its BP-lowering effect in young hypertensives. Similarly, no angiotensin II-dependent component in MSNA appears to be present at baseline or to be induced by amlodipine.