Addition of Manidipine Improves the Antiproteinuric Effect of Candesartan in Hypertensive Patients With Type II Diabetes and Microalbuminuria

These findings show that, despite equivalent reduction in BP, the addition of manidipine to candesartan further reduced the UAER, whereas the addition of HCTZ did not modify the UAER. This suggests that the antiproteinuric effect of manidipine is partially independent of BP reduction, and is attributable to mechanisms different from those mediated by angiotensin receptor blockade.