Long-Term Inhibition of the Central α2B-Adrenergic Receptor Gene Via Recombinant AAV-Delivered Antisense in Hypertensive Rats

These results indicate that our construct, when given by ICV means, could reach multiple sites of the central nervous system relevant to BP regulation and could safely inhibit the central α2B-adrenergic receptor, thereby achieving prolonged reversal of salt-induced hypertension.