کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2863141 | 1573122 | 2016 | 5 صفحه PDF | دانلود رایگان |
BackgroundThe aim of this study was to evaluate the prognostic value of D-dimer in patients with newly diagnosed de novo non-M3 subtypes of acute myeloid leukemia (AML).Materials and MethodsWe retrospectively analyzed the clinical data from 245 patients with newly diagnosed de novo non-M3 subtypes of AML at the Tongji Hospital from January 2010 to December 2014.ResultsThe comparison results indicated that the D-dimer values were higher in patients with AML with the following characteristics: WBC count ≥ 20 × 109/L (2.20 versus 6.00, P = 0.001), percentage of bone marrow (BM) blasts ≥ 60% (2.06 versus 5.69, P = 0.003), and poor-risk stratification (P < 0.001). Cox univariate regression analysis showed that overall survival was negatively affected by the following factors: age > 60 years, poor-risk stratification, BM blast cell count ≥60%, and D-dimer ≥1 μg/mL. Multivariate analysis showed that only age > 60 years (P < 0.001), BM blast cell counts ≥60% (P = 0.001) and D-dimer values ≥1 μg/mL (P = 0.014) were independent adverse prognostic factors.ConclusionsD-dimer ≥1 μg/mL is related to high tumor burden and can be considered as an independent prognostic factor in patients with de novo non-M3 AML.
Journal: The American Journal of the Medical Sciences - Volume 352, Issue 2, August 2016, Pages 129–133