کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2863370 1573148 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inverse Correlation Between Circulating Endothelial Progenitor Cells With CD34+CD133+ and the Severity of Coronary Atherosclerosis Assessed by Syntax Score
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Inverse Correlation Between Circulating Endothelial Progenitor Cells With CD34+CD133+ and the Severity of Coronary Atherosclerosis Assessed by Syntax Score
چکیده انگلیسی

BackgroundThe number of endothelial progenitor cells (EPCs) descends when atherosclerosis developed. The objective was to compare the number of CD34 + CD133 + cells with the severity of atherosclerosis assessed by Syntax score.MethodsThe study included 80 patients with stable angina undergoing coronary angiography. Patients were classified into single-vessel group, multiple-vessel group and normal group according to angiography. The percentage of CD34 + CD133 + cells in the mononuclear cells isolated from peripheral blood of different groups by flow cytometric analysis was compared. The quantity of CD34 + CD133 + EPCs was log transformed to improve normality (lgEPC). Syntax score was used in this study to assess the extent of coronary artery disease.Results:The level of lgEPC was lower in the single-vessel group than that in the normal group (− 3.42 ± 0.44 versus − 3.17 ± 0.39, P < 0.05), and the level of lgEPC was lower in the multiple-vessel group than that in the single vessel group (− 3.63 ± 0.31 versus − 3.42 ± 0.44, P < 0.05). An inverse correlation between lgEPC and Syntax score analyzed by linear regression.ConclusionsEPC level probably serves as a predictor of the development and severity of atherosclerosis on a cellular level. EPC, a relatively more important risk factor, perhaps protects against coronary artery disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of the Medical Sciences - Volume 347, Issue 6, June 2014, Pages 457–462
نویسندگان
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