Cytosolic Low Molecular Weight Protein-Tyrosine Phosphatase Activity and Clinical Manifestations of Diabetes

All these observations point to a negative effect of high cLMWPTP activity on clinical manifestation of diabetes in accordance with theoretical and experimental data and suggest that pharmacological decrease of cLMWPTP activity could have beneficial effects on the clinical evolution of this disease. Moreover, in diabetic subjects with high activity AcP1 genotype, an intensive treatment could help to prevent severe clinical manifestations.