کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2863726 | 1573179 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Scleroderma: The Need for Extreme Remedies
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Scleroderma is a multisystem disorder of unknown etiology, which presents major challenges for clinical management. Although it is usually classified as an autoimmune disorder, theories of pathogenesis also must consider the major contributions of vascular abnormalities and noninflammatory connective tissue accumulation to the disease manifestations. Premature mortality remains significant despite institution of earlier and more intense approaches to therapy. Advances in control of renal crisis including avoidance of glucocorticoids and early use of angiotensin system blockade have resulted in decreased prevalence of renal failure since this topic was reviewed in these grand rounds more than 25 years ago. Pulmonary complications including interstitial fibrosis and pulmonary hypertension are now major contributors to morbidity and mortality. Recent studies of interventions to suppress immune activity suggest that the fibrotic burden might be reduced by such an approach, raising the possibility that some organ damage might be halted or even reversed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of the Medical Sciences - Volume 342, Issue 5, November 2011, Pages 416-421
Journal: The American Journal of the Medical Sciences - Volume 342, Issue 5, November 2011, Pages 416-421
نویسندگان
Nancy J. MD, Biff F. (Editor),