Relative Resistance to Oral Theophylline Treatment in Patients With Hyposmia Manifested by Decreased Secretion of Nasal Mucus Cyclic Nucleotides

Some patients with hyposmia with initially low nasal mucus cAMP and cGMP levels may be relatively resistant to oral theophylline treatment. This result may offer a mechanism of response lack among some patients whose smell function did not improve after oral theophylline treatment although other factors may influence their response lack.