Plasma Superoxide Radical in Jaundiced Patients and Role of Xanthine Oxidase

These data show that increased superoxide radical in the plasma of jaundiced patients is possibly formed from a source in the cytoplasmic membrane of blood cells and secreted into plasma. The reversal of this phenomenon by allopurinol, ex vivo, indicates that a blood cell membranous XO might be the source of increased plasma superoxide radical in patients with extrahepatic cholestasis.