کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2865255 | 1573241 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oncogenic Osteomalacia in a Case with a Maxillary Sinus Mesenchymal Tumor
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
We herein describe the rare case of a 41-year-old woman with oncogenic osteomalacia due to a tumor in the maxillary sinus who presented with chronic general pain that had been gradually deteriorating. The patient's laboratory findings revealed hypophosphatemia due to renal phosphate wasting, an inappropriately low serum 1α,25-dihydroxyvitamin D3 level for hypophosphatemia and an unusually high serum level of fibroblast growth factor 23 (FGF23). The causative tumor was surgically removed, resulting in a rapid resolution of the patient's biochemical abnormalities. An improvement of the abnormal multiple deposits on 99Technetium-methylene diphosphonate bone scintigraphy and an increase in the bone metabolism markers suggested the development of bone remodeling within 49 days after the operation. The pathologic diagnosis of the tumor was a “phosphaturic mesenchymal tumor, mixed with a connective tissue variant.” The expression of FGF23 was demonstrated in the tumor by the immunohistochemical techniques and a Western analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of the Medical Sciences - Volume 332, Issue 3, September 2006, Pages 142-147
Journal: The American Journal of the Medical Sciences - Volume 332, Issue 3, September 2006, Pages 142-147
نویسندگان
Nobuyuki MD, PhD, Mitsuhiro MD, PhD, Chuwa MD, PhD, Kengo MD, PhD, Yuichi MD, PhD, Takuro PhD, Hiroki PhD,