Preventing Oxidative Stress in Rats with Aldosteronism by Calcitriol and Dietary Calcium and Magnesium Supplements

The appearance of SHPT in aldosteronism, induced by fallen plasma [Ca2+]o, leads to PTH-mediated Ca2+ overloading of PBMC and their increased production of H2O2. SHPT in rats with aldosteronism can be prevented by calcitriol and a diet supplemented with Ca2+ and Mg2+. These findings raise the prospect that the SHPT found in CHF could be managed with macro- and micronutrients.