کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2902970 1173384 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid Effect of Inhaled Ciclesonide in Asthma : A Randomized, Placebo-Controlled Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Rapid Effect of Inhaled Ciclesonide in Asthma : A Randomized, Placebo-Controlled Study
چکیده انگلیسی

BackgroundCiclesonide is a novel inhaled corticosteroid for the treatment of asthma, and it is important to measure the onset of effect of this therapy on airway hyperresponsiveness (AHR), exhaled nitric oxide (NO), and levels of eosinophils in induced sputum.MethodsIn a randomized, double-blind, crossover study, 21 patients with mild asthma inhaled ciclesonide 320 μg (ex-actuator) qd, ciclesonide 640 μg (ex-actuator) bid, and placebo for 7 days. Exhaled NO and AHR to adenosine monophosphate (AMP), measured as the provocative concentration of AMP producing a 20% reduction in FEV1 (PC20FEV1), were assessed after inhalation on days 1, 3 and 7. Eosinophil levels in induced sputum were also measured.ResultsCiclesonide 320 μg qd and 640 μg bid produced significantly greater improvements in PC20FEV1 compared with placebo on day 1 (within 2.5 h), and on days 3 and 7 (all p < 0.0001). On day 3, both ciclesonide doses significantly reduced exhaled NO levels by − 17.7 parts per billion (p < 0.0001) and − 15.4 parts per billion (p < 0.003) vs placebo, respectively. Significant reductions were maintained during the study with both ciclesonide doses (p < 0.01). A nonsignificant trend towards a decrease in eosinophil cell numbers was observed after 7 days of ciclesonide treatment, especially in patients receiving the higher dose.ConclusionsA single dose of ciclesonide decreased AHR to AMP and exhaled NO within 3 h, while FEV, improved at 3 days and 7 days.Trial registrationClinicalTrials.gov Study ID Number BY9010/M1-125.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 134, Issue 4, October 2008, Pages 740–745
نویسندگان
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