کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2905631 1173433 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systemic Inflammation in Patients With COPD and Pulmonary Hypertension
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Systemic Inflammation in Patients With COPD and Pulmonary Hypertension
چکیده انگلیسی

Study objectivesCOPD is a systemic disorder that is associated with increases of inflammatory proteins in systemic circulation. However, no data on the potential role of systemic inflammation in pulmonary hypertension secondary to COPD are available. Therefore, our aim was to investigate the degree of systemic inflammation reflected by circulatory levels of C-reactive protein (CRP), tumor-necrosis factor (TNF)-α, and interleukin (IL)-6 in COPD patients with and without pulmonary hypertension.DesignCross-sectional study.SettingUniversity hospital, tertiary referral setting.Patients and measurementsIn 43 consecutive patients with COPD (mean [± SD] age, 65.0 ± 10.5 years; mean FEV1, 46.2 ± 18.1% predicted), lung function was assessed using body plethysmography; pulmonary artery pressure (Ppa) levels were measured by echocardiography. Serum TNF-α and IL-6 levels were assessed by enzyme-linked immunosorbent assay, and high-sensitivity serum CRP levels were measured by chemiluminescent immunoassay.ResultsPulmonary hypertension was present in 19 patients and was absent in 24 patients. In patients with pulmonary hypertension, serum CRP and TNF-α levels were significantly higher than in those patients without hypertension (median, 3.6 mg/L [25th to 75th percentile, 1.4 to 13.0 mg/L] vs 1.8 mg/L [25th to 75th percentile, 0.8 to 2.8 mg/L; p = 0.034]; and median, 4.2 pg/mL [25th to 75th percentile, 3.4 to 10.9 pg/mL] vs 3.1 pg/mL [25th to 75th percentile, 2.1 to 4.2 pg/mL]; p = 0.042, respectively). No differences were seen in serum IL-6 (median, 10.4 pg/mL [25th to 75th percentile, 8.8 to 12.2 pg/mL] vs 10.5 pg/mL [25th to 75th percentile, 9.4 to 39.1 pg/mL]; p = 0.651) between the groups. In multiple linear regression analysis, the following two variables were independent predictors of systolic Ppa (R2 = 0.373): Pao2 (p = 0.011); and log-transformed serum CRP level (p = 0.044).ConclusionWe conclude that increases in Ppa in patients with COPD are associated with higher serum levels of CRP and TNF-α, raising the possibility of a pathogenetic role for low-grade systemic inflammation in the pathogenesis of pulmonary hypertension in COPD patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 130, Issue 2, August 2006, Pages 326–333
نویسندگان
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