کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2910416 | 1174625 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diabetes in cystic fibrosis: A 2008 state of the art
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Cystic fibrosis (CF), a common autosomal recessive condition, often involves the CFTR ÎF508 mutation in the homo- or heterozygous state. Due to continuously improving survival rates, a secondary form of diabetes mellitus (cystic fibrosis-related diabetes or CFRD) is now becoming a major comorbidity associated with CF. The etiopathogeny of CFRD is usually ascribed to pancreatic exocrine/endocrine insufficiency which itself correlates with CFTR mutation. While insulin deficiency seems to play the major role in CFRD, a relative insulin resistance component was also proposed. In a local cohort of seventy-six patients with the ÎF508 mutation, we demonstrate using HOMA (Homeostasis Model Assessment) that impairment of the true underlying insulin secretion, as reflected by (BÂ ÃÂ S), is the hallmark of (pre)diabetes in CF. The initiation of insulin therapy is associated with a significant increase in body mass index as well as a trend towards improvement in lung function. Regular screening for (pre)diabetes in CF should on that ground be performed on a regular basis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes & Metabolic Syndrome: Clinical Research & Reviews - Volume 2, Issue 1, February 2008, Pages 77-80
Journal: Diabetes & Metabolic Syndrome: Clinical Research & Reviews - Volume 2, Issue 1, February 2008, Pages 77-80
نویسندگان
Vanessa Preumont, Michel P. Hermans, Martin Buysschaert,