کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2912311 1575471 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of the Minimum Effective Concentration of Foam Sclerosant in an Ex-vivo Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Evaluation of the Minimum Effective Concentration of Foam Sclerosant in an Ex-vivo Study
چکیده انگلیسی

BackgroundFoam sclerosants are widely used in sclerotherapy and have been accepted as more effective than the liquid form; however, there is no consensus about the most applicable and effective concentration.ObjectiveThe aim of this study was to investigate the histopathological changes caused by various widely used concentrations of foam sclerosant.MethodsFifty-six varicose vein segments of 5–10 mm diameter were gently resected and exposed to various concentrations of foam sclerosant (0.5%, 1%, 2%, 3%) for 5 min, and were then prepared for routine histopathological examination. A total damage scoring system, including the presence of endothelial swelling, intimal thickening, cellular vacuolization in the muscle layer, edema in the tunica media and extent of necrosis, was established.ResultsThe total damage score of the foam sclerosant groups was significantly higher than that of the control group (median 2.75 vs 1, p = 0.007). The highest damage score was achieved by 1% and 2% foam sclerosants (3.5 and 2.5). No significant difference was found among the different concentrations of sclerosant, although the 1% group caused more severe damage at a near significant level (p = 0.074).ConclusionSignificant pathological damage can be caused by even the lowest doses of foam sclerosant. The most injurious concentrations were found to be 1% and 2%, morphologically. A working concentration of 1% could thus be preferable to 0.5%, especially in larger veins. Further in-vivo studies are needed in order to validate these findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Vascular and Endovascular Surgery - Volume 44, Issue 6, December 2012, Pages 593–597
نویسندگان
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