کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2913942 1575502 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abdominal Aortic Aneurysm Rupture is not Associated with an Up-regulation of Inflammation within the Aneurysm Wall
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Abdominal Aortic Aneurysm Rupture is not Associated with an Up-regulation of Inflammation within the Aneurysm Wall
چکیده انگلیسی

BackgroundThe nature of the inflammatory change within ruptured AAA has not been extensively reported. The aim of this study was to compare the inflammatory response in non-ruptured and ruptured aneurysms with emphasis on the site of rupture.MethodsNon-rupture site biopsies were taken from the anterior aneurysm sac of non-ruptured (n = 31) and ruptured AAA (n = 20). In 12 ruptured AAA, a further biopsy was taken from the rupture site. Enzyme-linked immunosorbent assay was used to quantify IL-6, IL-1beta and TNF-alpha. Quantitative immunohistochemistry was undertaken for generic lymphocytes, T-cells, and B-cells.ResultsComparing biopsies in non-ruptured AAA versus a non-rupture site biopsy from ruptured AAA; there was no significant difference in IL-6, IL-1β, TNF-alpha, generic lymphocytes, T-cell or B-cell content. Comparing ruptured AAA – non-rupture site with rupture site; IL-6 and TNF-alpha were unchanged. By contrast IL-1β and lymphocytes were lower at the rupture site compared to the non-rupture site (IL-1β 1.39 ng/mg [0.97–2.29] vs. 1.92 ng/mg [1.46–2.57], p = 0.027; generic lymphocytes 2.89% [0.51–5.51] vs. 4.73% [2.27–12.40], p = 0.018; T-cells 0.28% [0.04–1.18] vs. 0.82% [0.40–1.36], p = 0.027; B-cells 0.16% [0.04–1.14] vs. 1.30% [0.32–5.40], p = 0.021).ConclusionsThese findings suggest the biological events leading to AAA rupture may not be dependent on an up-regulation in the inflammatory process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Vascular and Endovascular Surgery - Volume 40, Issue 2, August 2010, Pages 191–195
نویسندگان
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