کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2918398 1175692 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship Between Mean Platelet Volume and Coronary Blood Flow in Patients with Atrial Fibrillation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relationship Between Mean Platelet Volume and Coronary Blood Flow in Patients with Atrial Fibrillation
چکیده انگلیسی

IntroductionAtrial fibrillation (AF) is associated with impaired coronary flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC). Mean platelet volume (MPV) is elevated in patients with AF. In the present study we aimed to investigate the relationship between MPV and TFC in patients with AF in the absence of obstructive coronary artery disease (CAD).MethodsThis observational study enrolled 185 AF patients and 189 control subjects, all with angiographically documented normal coronary arteries. MPV was measured at baseline and mean TFC was assessed after diagnostic coronary angiography.ResultsThe MPV was 9.95 ± 1.32 in the AF group and 9.02 ± 1.16 in the control group (p < 0.001). In AF patients, MPV was significantly correlated with mean TFC (r = 0.419, p < 0.001), AF duration (r = 0.407, p < 0.001), AF classification (r = 0.378, p < 0.001), systemic hypertension (r = 0.165, p = 0.024), diabetes mellitus (r = 0.233, p = 0.001), left ventricular ejection fraction (r = −0.347, p < 0.001), and baseline use of diuretics (r = 0.177, p = 0.016). In linear regression analysis, mean TFC, left ventricular ejection fraction and diabetes mellitus were found to be independently associated with MPV (p < 0.001, p = 0.028 and p = 0.045 respectively).ConclusionMean platelet volume seems to be independently associated with coronary blood flow in patients with atrial fibrillation in the absence of obstructive coronary artery disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart, Lung and Circulation - Volume 22, Issue 1, January 2013, Pages 43–49
نویسندگان
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