کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2923041 1175862 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Shocks burden and increased mortality in implantable cardioverter-defibrillator patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Shocks burden and increased mortality in implantable cardioverter-defibrillator patients
چکیده انگلیسی

BackgroundImplantable cardioverter-defibrillator (ICD) shocks are associated with an increased risk of death. It is unclear whether ICD shocks are detrimental per se or a marker of higher risk patients.ObjectiveWe aimed to assess the association between ICD shocks and time to death after correction for baseline mortality based on the Seattle Heart Failure Model (SHFM).MethodsThe primary analysis compared time-to-death between patients receiving no shocks and patients receiving shocks of any type adjusted for SHFM score at time of implantation and other comorbidities. Subgroup analyses were performed to further describe the relationship between shocks and mortality risk.ResultsOver a median follow-up of 41 months (interquartile range 23–64), one or more shock episodes occurred in 59% of 425 patients and 40% of the patients died. Patients receiving shocks of any type had increased risk of death (hazard ratio 1.55; 95% confidence interval 1.07–2.23; P = .02) versus patients receiving no shocks. While patients with 1–5 days with shock (shock days) did not show evidence of increased risk of death (1.30 [0.88–1.94]; P = 0.19), those with 6–10 shock days (2.22 [1.21–4.08]; P <.01) and >10 shock days (3.66 [1.86–7.19]; P <.01) had increasingly higher risk. There was no increased hazard for death (0.73 [0.34–1.57]; P = .41) in patients treated only with antitachycardia pacing (ATP).ConclusionICD shocks were associated with increased mortality risk after adjustment for SHFM-predicted mortality, and the burden of shocks played a role in this association. ATP did not increase mortality risk, suggesting that shocks may themselves be detrimental.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 8, Issue 12, December 2011, Pages 1881–1886
نویسندگان
, , , , ,