کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2923137 1175864 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of coronary sinus musculature in the induction of atrial fibrillation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The role of coronary sinus musculature in the induction of atrial fibrillation
چکیده انگلیسی

BackgroundCoronary sinus (CS) musculature connects the right atria (RA) and the left atria (LA). However, the functional significance of the electrical junctions between the atria and the CS musculature is still unclear.ObjectiveWe investigated electrophysiological properties of the CS-atrial connections and their role in atrial fibrillation.MethodsBy using an optical mapping system, we mapped action potentials at 256 sites on the epicardial surface of 16 isolated and arterial-perfused canine atrial tissues containing the entire musculature of the CS, lower RA, posterior LA, left inferior pulmonary vein, and vein of Marshal. We paced from each of the above regions to measure electrophysiological properties and inducibility of atrial tachyarrhythmias.ResultsThe CS musculature connected to the RA at the ostium of the CS and to the LA at proximal and distal CS sites. Electrical conduction across each of these CS-atrial junctions was slow (P < .01), but not decremental. Rapid pacing often induced entrance block at the CS-atrial junctions and resulted in sequential changes of activation sequence in the CS. Macroreentrant circuit involving the CS musculature and the CS-atrial junctions occurred in association with conduction block at these junctions. The reentrant circuit was usually unstable and resulted in atrial fibrillation–like electrocardiographic activity.ConclusionsThe anatomical and electrical connections between the CS musculature and the RA and the LA caused conduction slowing and block in the CS musculature and its atrial junctions, which frequently initiated unstable macroreentry and atrial fibrillation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 9, Issue 4, April 2012, Pages 581–589
نویسندگان
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