کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2925064 1175928 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term outcomes of left bundle branch block in high-risk survivors of acute myocardial infarction: The VALIANT experience
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Long-term outcomes of left bundle branch block in high-risk survivors of acute myocardial infarction: The VALIANT experience
چکیده انگلیسی

BackgroundIn survivors of myocardial infarction (MI), new left bundle branch block (LBBB) is associated with adverse outcomes, but its impact is not well described in post-MI patients with left ventricular (LV) systolic dysfunction and/or heart failure (HF).ObjectivesThe aim of this study was to determine if new LBBB is an independent predictor of long-term fatal and nonfatal outcomes in high-risk survivors of MI by reviewing data from the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial.MethodsIn VALIANT, 14,703 patients with LV systolic dysfunction and/or HF were randomized to valsartan, captopril, or both a mean of 5 days after MI. Baseline ECG data were available from 14,259 patients. We assessed the predictive value of new LBBB for death and major cardiovascular outcomes after 3 years, adjusting for multiple baseline covariates including LV ejection fraction.ResultsAt follow-up, patients with new LBBB (608 [4.2%]) compared with patients without new LBBB had more comorbidities and increased adjusted risk of death (hazard ratio [HR] 1.3, 95% confidence interval [CI] 1.2–1.6), cardiovascular death (HR 1.4, 95% CI 1.2–1.7), HF (HR 1.3, 95% CI 1.1–1.6), MI (HR 1.5, 95% CI 1.2–1.9), and the composite of death, HF, or MI (HR 1.4, 95% CI 1.2–1.6).ConclusionIn post-MI survivors with LV systolic dysfunction and/or HF, new LBBB was an independent predictor of all major adverse cardiovascular outcomes during long-term follow-up. This readily available ECG marker should be considered a major risk factor for long-term cardiovascular complications in high-risk patients after MI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 4, Issue 3, March 2007, Pages 308–313
نویسندگان
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