کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2932644 1576318 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal complication of pregnancy in Marfan syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Maternal complication of pregnancy in Marfan syndrome
چکیده انگلیسی

ObjectivesEvaluate the risk of aortic complications (aortic dissection or prophylactic aortic surgical replacement) associated with pregnancy in Marfan syndrome in the absence of specific care.BackgroundData are scarce on aortic complications during pregnancy in Marfan syndrome.MethodsRetrospective study on a large population (415 patients) followed up in our multidisciplinary out-patient clinic devoted to Marfan syndrome. Women over 18 years of age were divided into 2 groups: 85 had been pregnant (MFSP+) giving birth to 136 children through 160 pregnancies; 68 had not been pregnant (MFSP−). The occurrence of aortic complication was compared between the 2 groups using a piecewise discrete-time model.ResultsIn MFSP+, 7 aortic complications occurred during 160 pregnancies (4.4%) and 17 aortic complications occurred during 1870 years of follow-up out of pregnancy. In MFSP−, 14 aortic complications occurred over 940 years of follow-up. Pregnancy was associated with a 5 fold increase in risk of aortic complication, which did not translate into increased risk during life, suggesting that pregnancy may act as a revealer in women prone to aortic complication.ConclusionsPregnancy is associated with a transient increased risk of aortic complication in the absence of specific care.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 136, Issue 2, 14 August 2009, Pages 156–161
نویسندگان
, , , , , , ,