کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2933152 1576310 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiac involvement in a female carrier of Duchenne muscular dystrophy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Cardiac involvement in a female carrier of Duchenne muscular dystrophy
چکیده انگلیسی

A 42 year-old female carrier of Duchenne muscular dystrophy (DMD) was referred with suspected subacute myocarditis and non-sustained ventricular tachycardia. Echochardiography and cardiac catheterization revealed severely reduced left ventricular function (LVF). Coronary artery disease was excluded. Cardiac magnetic resonance imaging showed transmural, intramural and subepicardial late gadolinium enhancement. Myocardial biopsy excluded viral infection and showed severe myopathic changes with abnormal expression of dystrophin and utrophin. Moleculargenetic analysis of the DMD gene revealed frameshift duplication of exon 2. The patient received conventional heart failure therapy, implantable cardioverter/defibrillator-implantation and prednisolone to attenuate cardiac degradation. 6 months later she had improved clinically though LVF was still severely reduced.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 138, Issue 3, 4 February 2010, Pages 302–305
نویسندگان
, , , , , , ,