Incidence and predictors of drug-eluting stent fractures in long coronary disease

BackgroundStent fractures after drug-eluting stent (DES) implantation have not been evaluated sufficiently in patients with long coronary artery disease.MethodsThis study comprised of 415 patients, who were enrolled in the Long-DES-II study and had a complete serial angiography both before and after procedure and also at follow-up. The lesions were ≥ 25 mm in length and were randomly treated with sirolimus-eluting stents (SES, 210 lesions) or paclitaxel-eluting stent (205 lesions).ResultsDES fracture was identified in 7 lesions (1.7%): 1 minor, 3 moderate, and 3 severe fractures. Most of the fractures occurred in patients who received SES (85.7%) and in the right coronary artery (RCA) lesions (71.4%). Lesions with fracture had a smaller minimal lumen diameter before procedure than lesions without fracture (0.38 ± 0.55 vs. 0.71 ± 0.46 mm, p = 0.043). However, acute gain (2.28 ± 0.39 vs. 1.44 ± 0.60 mm, p = 0.001) and late loss (0.81 ± 0.49 vs. 0.42 ± 0.50 mm, p = 0.033) in analysis segment were greater in lesions with fracture. By multivariate analysis, the independent predictor of fracture was the RCA lesion (Odds ratio, 7.81; 95% CI, 1.45 ∼ 42.04; p = 0.017). Although one patient had an intermediate angiographic narrowing at the fracture site, there was no adverse cardiac event related with fracture.ConclusionsThe incidence of stent fracture in long DES implantation was not common and was associated with SES implantation or RCA lesions. Fortunately, the clinical prognosis of DES fracture was somewhat benign.