کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2942107 1177101 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heterogeneous Arterial Healing in Patients Following Paclitaxel-Eluting Stent Implantation : Comparison With Sirolimus-Eluting Stents
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Heterogeneous Arterial Healing in Patients Following Paclitaxel-Eluting Stent Implantation : Comparison With Sirolimus-Eluting Stents
چکیده انگلیسی

ObjectivesWe angioscopically compared paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) to explore differences in arterial healing.BackgroundDrug-eluting stents may demonstrate different arterial healing processes.MethodsAngioscopy was performed 9 ± 2 months after 30 PES and 36 SES were implanted initially in the native coronary artery. Heterogeneity of the neointimal coverage (NIC) as well as the dominant grade was examined. Neointimal coverage was defined as follows: grade 0 = fully visible struts; grade 1 = struts bulged into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. Heterogeneity was judged when the NIC grade variation ≥1. Thrombi and yellow plaques (YP) were also explored.ResultsIn-stent late loss (0.44 ± 0.44 mm vs. 0.13 ± 0.33 mm; p < 0.0001) and dominant NIC grade (1.8 ± 1.1 vs. 1.3 ± 0.7; p = 0.02) were greater in PES than in SES. Of PES, 48% showed the heterogeneity of 1 grade; 26% showed that of 2 grades. Of SES, 53% showed homogeneous coverage; the remaining SES showed the heterogeneity of 1 grade; and 72% showed dominant grade 1. Thrombi were more common in PES than in SES (43% vs. 19%; p = 0.04). Both stents commonly revealed YP (83% vs. 78%; p = 0.76).ConclusionsNIC was more heterogeneous in PES, associated with a higher incidence of thrombi. Homogeneous NIC may be an important factor for competent arterial healing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: JACC: Cardiovascular Interventions - Volume 2, Issue 5, May 2009, Pages 453–458
نویسندگان
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