کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2942284 1576603 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Temporal Stability of Rotors and Atrial Activation Patterns in Persistent Human Atrial Fibrillation : A High-Density Epicardial Mapping Study of Prolonged Recordings
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Temporal Stability of Rotors and Atrial Activation Patterns in Persistent Human Atrial Fibrillation : A High-Density Epicardial Mapping Study of Prolonged Recordings
چکیده انگلیسی

ObjectivesThis study aimed to determine the spatiotemporal stability of rotors and other atrial activation patterns over 10 min in longstanding, persistent AF, along with the relationship of rotors to short cycle-length (CL) activity.BackgroundThe prevalence, stability, and mechanistic importance of rotors in human atrial fibrillation (AF) remain unclear.MethodsEpicardial mapping was performed in 10 patients undergoing cardiac surgery, with bipolar electrograms recorded over 10 min using a triangular plaque (area: 6.75 cm2; 117 bipoles; spacing: 2.5 mm) applied to the left atrial posterior wall (n = 9) and the right atrial free wall (n = 4). Activations were identified throughout 6 discrete 10-s segments of AF spanning 10 min, and dynamic activation mapping was performed. The distributions of 4,557 generated activation patterns within each mapped region were compared between the 6 segments.ResultsThe dominant activation pattern was the simultaneous presence of multiple narrow wave fronts (26%). Twelve percent of activations represented transient rotors, seen in 85% of mapped regions with a median duration of 3 rotations. A total of 87% were centered on an area of short CL activity (<100 ms), although such activity had a positive predictive value for rotors of only 0.12. The distribution of activation patterns and wave-front directionality were highly stable over time, with a single dominant pattern within a 10-s AF segment recurring across all 6 segments in 62% of mapped regions.ConclusionsIn patients with longstanding, persistent AF, activation patterns are spatiotemporally stable over 10 min. Transient rotors can be demonstrated in the majority of mapped regions, are spatiotemporally associated with short CL activity, and, when recurrent, demonstrate anatomical determinism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: JACC: Clinical Electrophysiology - Volume 1, Issues 1–2, March–April 2015, Pages 14–24
نویسندگان
, , , , , , , , , , , , , ,