کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2944027 1577069 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pre-Morbid Body Mass Index and Mortality After Incident Heart Failure : The ARIC Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Pre-Morbid Body Mass Index and Mortality After Incident Heart Failure : The ARIC Study
چکیده انگلیسی

BackgroundAlthough obesity is an independent risk factor for heart failure (HF), once HF is established, obesity is associated with lower mortality. It is unclear if the weight loss due to advanced HF leads to this paradoxical finding.ObjectivesThis study sought to evaluate the prognostic impact of pre-morbid obesity in patients with HF.MethodsIn the ARIC (Atherosclerosis Risk In Communities) study, we used body mass index (BMI) measured ≥6 months before incident HF (pre-morbid BMI) to evaluate the association of overweight (BMI 25 to <30 kg/m2) and obesity (BMI ≥30 kg/m2) compared with normal BMI (18.5 to <25 kg/m2) with mortality after incident HF.ResultsAmong 1,487 patients with incident HF, 35% were overweight and 47% were obese by pre-morbid BMI measured 4.3 ± 3.1 years before HF diagnosis. Over 10-year follow-up after incident HF, 43% of patients died. After adjustment for demographics and comorbidities, being pre-morbidly overweight (hazard ratio [HR]: 0.72; 95% confidence interval [CI]: 0.58 to 0.90; p = 0.004) or obese (HR: 0.70; 95% CI: 0.56 to 0.87; p = 0.001) had a protective association with survival compared with normal BMI. The protective effect of overweight and obesity was consistent across subgroups on the basis of a history of cancer, smoking, and diabetes.ConclusionsOur results, for the first time, demonstrate that patients who were overweight or obese before HF development have lower mortality after HF diagnosis compared with normal BMI patients. Thus, weight loss due to advanced HF may not completely explain the protective effect of higher BMI in HF patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 64, Issue 25, 30 December 2014, Pages 2743–2749
نویسندگان
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