کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2945043 1577131 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Noninvasive Detection of Lipids in Atherosclerotic Plaque Using Ultrasound Thermal Strain Imaging : In Vivo Animal Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Noninvasive Detection of Lipids in Atherosclerotic Plaque Using Ultrasound Thermal Strain Imaging : In Vivo Animal Study
چکیده انگلیسی

ObjectivesThis study sought to examine the feasibility of in vivo detection of lipids in atherosclerotic plaque (AP) by ultrasound (US) thermal (or temporal) strain imaging (TSI).BackgroundIntraplaque lipid content is thought to contribute to plaque stability. Lipid exhibits a distinctive physical characteristic of temperature-dependent US speed compared with water-bearing tissues. As tissue temperature changes, US radiofrequency (RF) echoes shift in time of flight, which produces an apparent strain (thermal or temporal strain [TS]).MethodsUS heating-imaging pulse sequences and transducers were designed and integrated into commercial US scanners for US-TSI of arterial segments. US-RF data were collected while gradually increasing tissue temperature. Phase-sensitive speckle tracking was applied to reconstruct TS maps coregistered to B-scans. Segments from injured atherosclerotic and uninjured nonatherosclerotic common femoral arteries (CFA) in cholesterol-fed New Zealand rabbits, and segments from control normal diet–fed rabbits (N =14) were scanned in vivo at different time points up to 12 weeks.ResultsLipid-rich atherosclerotic lesions exhibited distinct positive TS (+0.19 ± 0.08%) compared with that in nonatherosclerotic (–0.10 ± 0.13%) and control (–0.09 ± 0.09%) segments (p < 0.001). US-TSI enabled serial monitoring of lipids during atherosclerosis development. The coregistered set of morphological and compositional information of US-TSI showed good agreement with histology.ConclusionsUS-TSI successfully detected and longitudinally monitored lipid progression in atherosclerotic CFA. US-TSI of relatively superficial arteries may be a modality that could be integrated into a commercial US system for noninvasive lipid detection in AP.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 62, Issue 19, 5 November 2013, Pages 1804–1809
نویسندگان
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